Optimizing MSL Impact in Clinical Trials: Engaging Primary Investigators for Improved Patient Enrollment Metrics

CASE STUDY (US)

The Challenge 

A client approached us to support their Phase III clinical trials. They needed to increase enrollment and expand awareness of their trials to referral sites in the US. They had an aggressive timeline and knew they needed field-ready Medical Science Liaisons (MSLs) who could bridge the communication gap between external and internal stakeholders.

“Excellent job with the quality of interactions with Key Opinion Leaders (KOLs) and healthcare professionals involved in our clinical trials.”

Our Solution

Leveraging our experience with clinical trial management, we focused on recruiting MSLs and leaders with proven success in Phase II/III trials. We sought professionals who could communicate effectively and collaborate with the client’s existing MSL teams and operations staff.

Within a short timeframe, we deployed a dedicated MSL manager and a team of 6 MSLs strategically located near the clinical trial sites. The internal training of the MSL team focused on cultivating therapeutic expertise, instilling a passion for enhancing trial productivity, and pinpointing critical areas of challenge.

We created relevant key performance indicators (KPIs) tied to the value of this hybrid MSL clinical trial role, including generating post-site initiation visit reports, sharing site insights with operations, leading site action plans, and supporting new site identification. The team received training on patient referrals, content development, and crafting collaborative action plans.

“We appreciate your contributions to the great progress we’ve made on the rate at which eligible patients are recruited and screened in the clinical trials, ensuring targets are met.”

The Results

Rapid Response: Deployed an experienced MSL team within strategic locations, achieving significant provider outreach and patient retention, critical to trial success.

Accelerated Enrollment: Our MSL team successfully facilitated patient enrollment goals within 12 months for two critical Phase III clinical trials in a rare disease within the immunology space.

High Engagement: Over 550 healthcare provider interactions were conducted, resulting in 240 and 121 activated referral networks for two separate trials, respectively.

Strategic Site Support: MSL-driven site-specific action plans addressed challenges and enhanced trial site engagement, leading to measurable increases in trial productivity.

Strengthened Leadership Communication: Weekly updates to client executive leadership ensured alignment, directly contributing to streamlined operations and site activation.

“The team is doing a fantastic job with timely reporting of clinical trial patient enrollment barriers & challenges.”

 

“Great job ensuring there’s constant communication & collaboration with our cross-functional partners.”